Enhancement of human mesenchymal stem cell differentiation by combination treatment with 5-azacytidine and trichostatin A

Abstract

To enhance the differentiation of mesenchymal stem cells (MSCs) and their epigenetic status by modification using hypomethylating agents (HMAs) and histone deacetylase inhibitors (HDACs). Treatment with 5-azacytidine or 5-azacytidine plus trichostatin A (TSA) increased expression of Runx-2, BDNF and Sox-9 compared with the control or TSA groups. Maximal… (More)
DOI: 10.1007/s10529-015-1949-3

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