Enhancement of human immunodeficiency virus type 1 infectivity by Nef is producer cell-dependent.

@article{Tokunaga1998EnhancementOH,
  title={Enhancement of human immunodeficiency virus type 1 infectivity by Nef is producer cell-dependent.},
  author={Kenzo Tokunaga and Asato Kojima and T. Kurata and Kazuyoshi Ikuta and Hirofumi Akari and A. Hajime Koyama and Meiko Kawamura and Ritsuko Inubushi and Reika Shimano and Akio Adachi},
  journal={The Journal of general virology},
  year={1998},
  volume={79 ( Pt 10)},
  pages={2447-53}
}
The growth kinetics of wild-type and nef mutant viruses of human immunodeficiency virus type 1 were comparatively analysed in several human CD4+ cell lines. Delayed replication of nef mutant virus was observed in all cell lines examined. To determine the stage in the virus replication cycle that is affected by Nef, a single-round replication assay was performed. Initially, the expression of marker genes in transfected cells was examined in order to study the role of Nef in the late phase of… CONTINUE READING

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