Enhancement of human T lymphocyte function by prothymosin alpha: increased production of interleukin-2 and expression of interleukin-2 receptors in normal human peripheral blood T lymphocytes.

Abstract

The in vitro incubation of phytohemagglutinin (PHA)- or alloantigen-stimulated peripheral blood T cells with prothymosin alpha (ProT alpha) resulted in a marked and reproducible increase in the production of interleukin-2 (IL-2). Incubation of T cells with ProT alpha, in the absence of PHA or alloantigen, failed to induce any production of IL-2. ProT alpha by itself did not exert any IL-2 activity. Finally, ProT alpha was shown to increase the expression of IL-2 receptors on phytohemagglutinin- or alloantigen-activated T cells. These data provide the basis for understanding the in vitro immunoenhancing effects of ProT alpha in cellular immune systems.

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@article{Baxevanis1990EnhancementOH, title={Enhancement of human T lymphocyte function by prothymosin alpha: increased production of interleukin-2 and expression of interleukin-2 receptors in normal human peripheral blood T lymphocytes.}, author={Constantin N. Baxevanis and Stathis Frillingos and Konstantinos I Seferiadis and G J Reclos and Panagiotis Arsenis and A Katsiyiannis and Elias Anastasopoulos and Orestes Tsolas and Michael Papamichail}, journal={Immunopharmacology and immunotoxicology}, year={1990}, volume={12 4}, pages={595-617} }