Enhancement of glycosylation of cellular glycoconjugates in the squamous carcinoma cell line MDA886Ln by β-all-trans retinoic acid

  title={Enhancement of glycosylation of cellular glycoconjugates in the squamous carcinoma cell line MDA886Ln by $\beta$-all-trans retinoic acid},
  author={Peter G. Sacks and Brad Amos and Reuben Lotan},
  journal={Glycoconjugate Journal},
Retinoids have been shown to inhibit the growth and modulate the glycosylation of head and neck squamous cell carcinoma (HNSCC) cells including the MDA886Ln cells. To examine the effects of β-all-trans retinoic acid (RA) on glycoconjugates in HNSCC MDA886Ln cells, the cells were grown in the absence or presence of 1 µM RA and then labeled with tritiated monosaccharides, extracted and analysed by polyacrylamide gel electrophoresis and fluorography. RA increased markedly the incorporation of [3H… 
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