Enhancement of glomerular heme oxygenase-1 expression in diabetic rats.

  title={Enhancement of glomerular heme oxygenase-1 expression in diabetic rats.},
  author={Kazuyuki Hayashi and Masakazu Haneda and Daisuke Koya and Shin Maeda and Keiji Isshiki and Ryuichi Kikkawa},
  journal={Diabetes research and clinical practice},
  volume={52 2},
An increase in oxidative stress in diabetic subjects is implicated to play a pivotal role in diabetic vascular complications. In response to oxidative stress, antioxidant enzymes are considered to be induced and protect cellular functions to keep in vivo homeostasis. However, it remains to be clarified whether antioxidant enzymes are induced against oxidative stress especially in renal glomeruli at an early stage of diabetes. To answer this question, we examined the gene expression of a variety… CONTINUE READING