Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin.

@article{Gupta2006EnhancementOG,
  title={Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin.},
  author={Vinay Gupta and Yuzhuang S Su and Weijun Wang and Adel Kardosh and Leonard F Liebes and Florence M. Hofman and Axel H Sch{\"o}nthal and Thomas C. Chen},
  journal={Neurosurgical focus},
  year={2006},
  volume={20 4},
  pages={
          E20
        }
}
OBJECT The chemotherapeutic agent temozolomide has demonstrated antitumor activity in patients with recurrent malignant glioma. Because responses are not enduring and recurrence is nearly universal, further improvements are urgently needed. METHODS In an effort to increase the clinical activity of temozolomide, the authors investigated whether its antitumor activity could be enhanced by adding tamoxifen or hypericin, two drugs that are known to inhibit the activity of protein kinase C. Human… CONTINUE READING

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