Enhancement of genotype 1 hepatitis C virus replication by bile acids through FXR.

@article{Scholts2008EnhancementOG,
  title={Enhancement of genotype 1 hepatitis C virus replication by bile acids through FXR.},
  author={Caroline Scholt{\`e}s and Olivier Diaz and Vinca Icard and Artur Kaul and Ralf Bartenschlager and Vincent Lotteau and Patrice Andr{\'e}},
  journal={Journal of hepatology},
  year={2008},
  volume={48 2},
  pages={192-9}
}
BACKGROUND/AIMS Hepatitis C virus (HCV) infected patients with high serum levels of bile acids (BAs) usually fail to respond to antiviral therapy. Besides, BAs are essential factors for replication of the porcine enteric calicivirus by inhibiting interferon signaling. The role of BAs on HCV RNA replication was thus assessed. METHODS BAs and other compounds were tested using an HCV-replication model containing a luciferase reporter gene. RESULTS BAs, especially chenodeoxycholate and… CONTINUE READING
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