Enhancement of gamma-aminobutyric acidA receptor activity by alpha-chloralose.

  title={Enhancement of gamma-aminobutyric acidA receptor activity by alpha-chloralose.},
  author={Kennon M. Garrett and J Gan},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={285 2},
alpha-Chloralose is widely used as an anesthetic in the laboratory due to its minimal effects on autonomic and cardiovascular systems, yet little is known about its mechanism of action. We examined the effects of alpha-chloralose on gamma-aminobutyric acid type A (GABAA) receptor activity because recent studies have shown that several classes of general anesthetics modulate the function of this receptor. GABAA receptor activity was assayed by measuring the GABA-induced current in Xenopus… CONTINUE READING


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