Enhancement of folates in plants through metabolic engineering.

  title={Enhancement of folates in plants through metabolic engineering.},
  author={Tahzeeba Hossain and Irwin H Rosenberg and Jacob S Selhub and Ganesh M. Kishore and Roger N. Beachy and Karel Schubert},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 14},
Humans depend on plants as a major source of dietary folates. Inadequate dietary levels of the vitamin folate can lead to megaloblastic anemia, birth defects, impaired cognitive development, and increased risk of cardiovascular disease and cancer. The biofortification of folate levels in food crops is a target for metabolic engineering. Folates are synthesized de novo from pterins and para-amino benzoic acid, which are subsequently combined to form dihydropteroate, the direct precursor to… CONTINUE READING