Enhancement of feeding suppression by PYY(3-36) in rats with area postrema ablations.

@article{Cox2004EnhancementOF,
  title={Enhancement of feeding suppression by PYY(3-36) in rats with area postrema ablations.},
  author={James E. Cox and Alan Randich},
  journal={Peptides},
  year={2004},
  volume={25 6},
  pages={985-9}
}
We investigated suppression of food intake by intraperitoneal (IP) injections of peptide YY(3-36) (PYY(3-36)) (24, 60, or 150 microg/kg) in rats with ablations of the area postrema (APX) and in controls with sham ablations. In controls, PYY(3-36)-induced suppression was modest and short-lived, averaging 20% at most and persisting less than 6h. The highest dose tested (150 microg/kg) was even less effective than were the two lesser doses after 3h. APX did not diminish the potency of these… CONTINUE READING

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