Enhancement of epitope-specific cellular immune responses by immunization with HIV-1 peptides genetically conjugated to the B-subunit of recombinant cholera toxin.

@article{Boberg2008EnhancementOE,
  title={Enhancement of epitope-specific cellular immune responses by immunization with HIV-1 peptides genetically conjugated to the B-subunit of recombinant cholera toxin.},
  author={Andreas Boberg and Stefan Gaunitz and Andreas Br{\aa}ve and Britta E. Wahren and Neal Carlin},
  journal={Vaccine},
  year={2008},
  volume={26 40},
  pages={5079-82}
}
As more HIV-1 infected patients receive anti-retroviral drug treatment, the occurrence of drug-resistant variants of the virus is increasing. We have previously shown that mutated HIV peptide sequences represent mutations induced by antiretroviral drugs are equally good and often better immunogens than wild type peptides. The non-toxic B subunit of cholera toxin (CTB) is an active substance in the oral cholera vaccine, and has been shown to bind ganglioside receptors and activate mucosal cells… CONTINUE READING