Enhancement of epidermal regeneration by biosynthetic epidermal growth factor

  title={Enhancement of epidermal regeneration by biosynthetic epidermal growth factor},
  author={Gregory L. Brown and L J Curtsinger and Joseph Brightwell and Debra Ackerman and G. R. Tobin and Hiram C. Polk and C George-Nascimento and Pablo Valenzuela and Greg S Schultz},
  journal={The Journal of Experimental Medicine},
  pages={1319 - 1324}
Epidermal regeneration depends on mitosis and migration of keratinocytes. Epidermal growth factor is known to stimulate growth of keratinocytes in vitro, thus it might be expected to promote wound healing. The results of this study show that topical application of biosynthetic human epidermal growth factor accelerates epidermal regeneration in split-thickness wounds and partial-thickness burns. The significant enhancement of epidermal regeneration suggests the potential for clinical use of… CONTINUE READING


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