Enhancement of endogenous release of glutamate and gamma-aminobutyric acid from hippocampus CA1 slices after in vivo long-term potentiation.

@article{Ghijsen1992EnhancementOE,
  title={Enhancement of endogenous release of glutamate and gamma-aminobutyric acid from hippocampus CA1 slices after in vivo long-term potentiation.},
  author={Wim E. J. M. Ghijsen and Elly Besselsen and Vincent G M Geukers and Willem Kamphuis and Fernando H. Lopes da Silva},
  journal={Journal of neurochemistry},
  year={1992},
  volume={59 2},
  pages={482-6}
}
The effect of long-term potentiation (LTP) on endogenous amino acid release from rat hippocampus slices was studied. LTP was induced in vivo by application of a tetanus (200 Hz, 200 ms) to the Schaffer collateral fibers in unanesthetized rats. Endogenous release of glutamate and gamma-aminobutyric acid (GABA) was investigated 60 min after tetanization in CA1 subslices of potentiated and control rats. No significant effects of LTP were observed in basal and K(+)-induced Ca(2+)-independent… CONTINUE READING