Enhancement of docetaxel-induced cytotoxicity and apoptosis by all-trans retinoic acid (ATRA) through downregulation of survivin (BIRC5), MCL-1 and LTbeta-R in hormone- and drug resistant prostate cancer cell line, DU-145

Abstract

BACKGROUND The management of hormone-refractory prostate cancer (HRPC) still remains as an important challenge of daily oncology practice. Docetaxel has proved to be a first line treatment choice. All-trans retinoic acid (ATRA) could potently inhibit the growth of prostate cancer cells in vitro and its combination with various anticancer agents results in… (More)
DOI: 10.1186/1756-9966-27-37

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@article{Kucukzeybek2008EnhancementOD, title={Enhancement of docetaxel-induced cytotoxicity and apoptosis by all-trans retinoic acid (ATRA) through downregulation of survivin (BIRC5), MCL-1 and LTbeta-R in hormone- and drug resistant prostate cancer cell line, DU-145}, author={Yuksel Kucukzeybek and Mustafa K. Gul and Ercument Cengiz and Çiğdem Erten and Burçak Karaca and Gurbuz Gorumlu and Harika Atmaca and Selim Uzunoğlu and Bulent Karabulut and Ulus All Sanli and Ruçhan Uslu}, journal={Journal of Experimental & Clinical Cancer Research : CR}, year={2008}, volume={27}, pages={37 - 37} }