Enhancement of dissolution and antioxidant activity of kaempferol using a nanoparticle engineering process.

@article{Tzeng2011EnhancementOD,
  title={Enhancement of dissolution and antioxidant activity of kaempferol using a nanoparticle engineering process.},
  author={Cheng-Wei Tzeng and F Y Yen and Tzu-Hui Wu and H H Ko and Chiang-Wen Lee and Wen-Sheng Tzeng and Chun-Ching Lin},
  journal={Journal of agricultural and food chemistry},
  year={2011},
  volume={59 9},
  pages={5073-80}
}
Kaempferol (KAE) is a strong antioxidant flavonoid compound, but its clinical application is limited by quantity and poor dissolution property. However, the dissolution mechanism of a kaempferol nanoparticle formulation (KAEN) has not yet been elucidated. The aim of the present study was therefore to use a nanoparticle engineering process to resolve the dissolution problem. Our data indicated that KAEN effectively increased the dissolution percentage by particle size reduction, high… CONTINUE READING

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