Enhancement of dissolution and antioxidant activity of kaempferol using a nanoparticle engineering process.

@article{Tzeng2011EnhancementOD,
  title={Enhancement of dissolution and antioxidant activity of kaempferol using a nanoparticle engineering process.},
  author={Cheng-Wei Tzeng and Feng-lin Yen and Tzu-hui Wu and Horng Huey Ko and Chiang-Wen Lee and Wen-Sheng Tzeng and Chun-ching Lin},
  journal={Journal of agricultural and food chemistry},
  year={2011},
  volume={59 9},
  pages={
          5073-80
        }
}
Kaempferol (KAE) is a strong antioxidant flavonoid compound, but its clinical application is limited by quantity and poor dissolution property. However, the dissolution mechanism of a kaempferol nanoparticle formulation (KAEN) has not yet been elucidated. The aim of the present study was therefore to use a nanoparticle engineering process to resolve the dissolution problem. Our data indicated that KAEN effectively increased the dissolution percentage by particle size reduction, high… Expand
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