Enhancement of dengue virus translation: role of the 3' untranslated region and the terminal 3' stem-loop domain.

@article{Holden2004EnhancementOD,
  title={Enhancement of dengue virus translation: role of the 3' untranslated region and the terminal 3' stem-loop domain.},
  author={Katherine Lynn Holden and Eva Harris},
  journal={Virology},
  year={2004},
  volume={329 1},
  pages={119-33}
}
An essential step for a productive infection by the dengue flavivirus (DEN) is translation of the m(7)G-capped, nonpolyadenylated positive-sense RNA genome. We have recently identified sequences within the DEN 3' untranslated region (UTR) that modulate viral translation. Here, we show that the DEN type 2 (DEN2) 3'UTR stimulated translation of m(7)G-capped DEN2 5'UTR-containing reporter mRNAs in baby hamster kidney (BHK) cells compared to a 3' vector sequence. Analogous to the 3' poly(A) tail… CONTINUE READING

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