Enhancement of cyclosporin production in a Tolypocladium inflatum strain after epichlorohydrin treatment.

Abstract

Following treatment of conidia of the cyclosporin producer fungus, Tolypocladium inflatum, with 0.15 M epichlorohydrin, strain M6 was isolated. The new strain exhibited a similar growth rate to the parent organism but more extensive conidiation and several-fold higher overall cyclosporin production. Strain M6 reached titres of 318 mg l-1 cyclosporin A in… (More)

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@article{Agathos1990EnhancementOC, title={Enhancement of cyclosporin production in a Tolypocladium inflatum strain after epichlorohydrin treatment.}, author={Spiros N. Agathos and Riddhish Parekh}, journal={Journal of biotechnology}, year={1990}, volume={13 1}, pages={73-81} }