Enhancement of chondrocyte autophagy is an early response in the degenerative cartilage of the temporomandibular joint to biomechanical dental stimulation

@article{Zhang2013EnhancementOC,
  title={Enhancement of chondrocyte autophagy is an early response in the degenerative cartilage of the temporomandibular joint to biomechanical dental stimulation},
  author={Mian Zhang and Jing Zhang and Lei Lu and Zhong-Ying Qiu and Xu Sunny Zhang and Shi-bin Yu and Yao-Ping Wu and Meiqing Wang},
  journal={Apoptosis},
  year={2013},
  volume={18},
  pages={423-434}
}
Autophagy is a cell protective mechanism for maintaining cellular homeostasis. The present study aimed to investigate whether autophagy is enhanced in the biomechanically induced degenerative cartilage of the temporomandibular joint (TMJ) and the potential role of mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) and mammalian Target of rapamycin (mTOR) in this observation. To induce degenerative changes in the TMJs, rats were subjected to biomechanical dental stimulation by… CONTINUE READING
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