Enhancement of cell recognition in vitro by dual-ligand cancer targeting gold nanoparticles.

@article{Li2011EnhancementOC,
  title={Enhancement of cell recognition in vitro by dual-ligand cancer targeting gold nanoparticles.},
  author={Xi Li and Hongyu Zhou and Lei Yang and Guoqing Du and Atmaram S Pai-Panandiker and Xuefei Huang and Bing Yan},
  journal={Biomaterials},
  year={2011},
  volume={32 10},
  pages={2540-5}
}
A dual-ligand gold nanoparticle (DLGNP) was designed and synthesized to explore the therapeutic benefits of multivalent interactions between gold nanoparticles (GNPs) and cancer cells. DLGNP was tested on human epidermal cancer cells (KB), which had high expression of folate receptor. The cellular uptake of DLGNP was increased by 3.9 and 12.7 folds compared with GNP-folate or GNP-glucose. The enhanced cell recognition was due to multivalent interactions between both ligands on GNPs and cancer… CONTINUE READING
21 Citations
35 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 35 references

Antibody-conjugated nanoparticles for biomedical applications

  • M Arruebo, M Valladares, A. Gonzalez-Fernandez
  • J Nanomater;
  • 2009
1 Excerpt

Similar Papers

Loading similar papers…