Enhancement of carboplatin- and quercetin-induced cell death by roscovitine is Akt dependent and p53 independent in hepatoma cells.

@article{Sharma2011EnhancementOC,
  title={Enhancement of carboplatin- and quercetin-induced cell death by roscovitine is Akt dependent and p53 independent in hepatoma cells.},
  author={Aanchal Sharma and Manoj Kumar Bhat},
  journal={Integrative cancer therapies},
  year={2011},
  volume={10 4},
  pages={NP4-14}
}
PURPOSE Hepatocellular carcinoma (HCC) is a common malignancy worldwide and has an annual occurrence of one million new cases. Novel therapeutic strategies of increased efficacy in the treatment of HCC-bearing patients would certainly be helpful. Hence, the authors explored the effect of combination treatment of roscovitine with chemotherapeutic drugs or quercetin (Qctn) in hepatoma cells, HepG2 and Hep3B. METHODS Cell viability was assessed by MTT assay, cell growth assay, and nuclear… CONTINUE READING

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