Enhancement of bovine growth hormone activity by antibodies against growth hormone peptides.

@article{Bomford1990EnhancementOB,
  title={Enhancement of bovine growth hormone activity by antibodies against growth hormone peptides.},
  author={R Bomford and Roger Aston},
  journal={The Journal of endocrinology},
  year={1990},
  volume={125 1},
  pages={31-8}
}
The biological activity of growth hormones can be enhanced by complexing with monoclonal antibodies of appropriate specificity. In order to define the regions associated with the phenomenon, site-directed antisera to ovine GH (oGH) were prepared by vaccination of sheep with synthetic peptides. Peptides from six distinct regions of the oGH molecule raised antibodies which recognized the hormone in solid-phase radioimmunoassay; however, only one peptide elicited high-affinity antibody as… CONTINUE READING