Enhancement of bioavailability of a hydrophobic amine antimalarial by formulation with oleic acid in a soft gelatin capsule.

@article{Stella1978EnhancementOB,
  title={Enhancement of bioavailability of a hydrophobic amine antimalarial by formulation with oleic acid in a soft gelatin capsule.},
  author={Valentino J. Stella and J. Haslam and Noboru Yata and Hirokazu Okada and Siegfried Lindenbaum and Tsunehiko Higuchi},
  journal={Journal of pharmaceutical sciences},
  year={1978},
  volume={67 10},
  pages={1375-7}
}
The relative availability of the orally administered hydrophobic antimalarial alpha-(dibutylaminomethyl)-6,8-dichloro-2-(3',4'-dichlorophenyl)-4-quinolinemethanol (I) from two dosage forms was determined in beagle dogs. Compound I was soluble in oleic acid to the extent of 23.5% (w/w), and oleic acid was suitable for encapsulation in soft gelatin capsules. The availability of I formulated as its hydrochloride salt in a standard hard gelatin capsule formulation was significantly lower than that… CONTINUE READING

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