Enhancement of binding of the dihydropyridine calcium antagonist PN200-110 to human myometrial sarcolemma by the heterologous calcium antagonist diltiazem.

Abstract

Binding of the dihydropyridine calcium antagonist PN200-110 was studied in human myometrial membranes. PN200-110 bound reversibly and with high affinity to membrane fragments. The highest concentration of binding sites was found in the sarcolemma. The benzothiazepine calcium antagonist diltiazem stimulated PN200-110 binding by increasing the amount bound at equilibrium. Kinetic studies detected a fast and slow rate of dissociation in the presence of diltiazem.

Cite this paper

@article{Golichowski1987EnhancementOB, title={Enhancement of binding of the dihydropyridine calcium antagonist PN200-110 to human myometrial sarcolemma by the heterologous calcium antagonist diltiazem.}, author={Alan M. Golichowski and D Y Tzeng}, journal={Biochemical pharmacology}, year={1987}, volume={36 7}, pages={1003-9} }