Enhancement of autophagic flux after neonatal cerebral hypoxia-ischemia and its region-specific relationship to apoptotic mechanisms.

@article{Ginet2009EnhancementOA,
  title={Enhancement of autophagic flux after neonatal cerebral hypoxia-ischemia and its region-specific relationship to apoptotic mechanisms.},
  author={Vanessa Ginet and Julien P. Puyal and Peter G. H. Clarke and Anita Carmen Truttmann},
  journal={The American journal of pathology},
  year={2009},
  volume={175 5},
  pages={1962-74}
}
The multiplicity of cell death mechanisms induced by neonatal hypoxia-ischemia makes neuroprotective treatment against neonatal asphyxia more difficult to achieve. Whereas the roles of apoptosis and necrosis in such conditions have been studied intensively, the implication of autophagic cell death has only recently been considered. Here, we used the most clinically relevant rodent model of perinatal asphyxia to investigate the involvement of autophagy in hypoxic-ischemic brain injury. Seven-day… CONTINUE READING