Enhancement of antitumor immunity of dendritic cells pulsed with heat-treated tumor lysate in murine pancreatic cancer.

@article{Kim2006EnhancementOA,
  title={Enhancement of antitumor immunity of dendritic cells pulsed with heat-treated tumor lysate in murine pancreatic cancer.},
  author={Han Soo Kim and Yee Shin Choo and Taeseok Koo and Seungmin Bang and Tae Yun Oh and Jing Wen and Si Young Song},
  journal={Immunology letters},
  year={2006},
  volume={103 2},
  pages={142-8}
}
Cancer vaccines using dendritic cells (DCs) have been shown to induce antitumor immunity and have recently been applied to non-immunogenic cancers, such as pancreatic cancer. In this study, we utilized DCs loaded with heat-treated tumor lysate (HTL-DC) as a vaccine in order to stimulate antitumor immunity in a murine pancreatic cancer model and compared them to DCs loaded with tumor lysate (TL-DC). The poorly immunogenic mouse ductal pancreatic cancer cell line PANC02 with syngeneic mouse… CONTINUE READING

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