Enhancement of antimalarial activity of chloramphenicol against Indian Plasmodium falciparum isolates in vitro by chloroquine.


The antimalarial activity of chloramphenicol, a broad-spectrum antibiotic was studied in three Indian Plasmodium falciparum isolates having high or low sensitivity to chloroquine. The antimalarial activity was evaluated in 72 hours culture in the presence of various doses of chloramphenicol alone or in combination with a fixed dose of chloroquine added at a… (More)