Enhancement of anti-tumor activity in vitro and in vivo by CD150 and SAP.

Abstract

Signaling lymphocyte activation molecule (SLAM, CD150) is a co-stimulatory receptor involved in T cell activation. The activity of CD150 is dependent on the intracellular signaling molecule SAP. Here, we investigated anti-CD3 activated human lymphocytes, transfected either with CD150-plasmid or with CD150- or SAP-siRNA in cytotoxicity assays against human… (More)

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@article{Mehrle2008EnhancementOA, title={Enhancement of anti-tumor activity in vitro and in vivo by CD150 and SAP.}, author={Stefan Mehrle and Jan Schmidt and Markus W. B{\"u}chler and Carsten Watzl and Angela M{\"a}rten}, journal={Molecular immunology}, year={2008}, volume={45 3}, pages={796-804} }