Enhancement of anti-neoplastic activity of cytosine arabinoside against human HL-60 myeloid leukemic cells by 3-deazauridine.

@article{Momparler1991EnhancementOA,
  title={Enhancement of anti-neoplastic activity of cytosine arabinoside against human HL-60 myeloid leukemic cells by 3-deazauridine.},
  author={Richard L. Momparler and David Y. Bouffard and Louise F. Momparler and J. W. Marquet and Jacqueline Zittoun and J. P. Marie and Robert Zittoun},
  journal={International journal of cancer},
  year={1991},
  volume={49 4},
  pages={573-6}
}
Drug resistance is one of the major reasons for failure of chemotherapy of acute leukemia with cytosine arabinoside (ARA-C). In order to overcome this problem we have investigated the interaction of ARA-C with 3-deazauridine (3-DU) against HL-60 myeloid leukemic cells. 3-DU is an interesting agent to use in combination with ARA-C, since drug-resistant cells that are deficient in deoxycytidine kinase are very sensitive to this uridine analogue. We have observed that for both short and long drug… CONTINUE READING