Enhancement of anandamide formation in the limbic forebrain and reduction of endocannabinoid contents in the striatum of delta9-tetrahydrocannabinol-tolerant rats.

@article{Marzo2000EnhancementOA,
  title={Enhancement of anandamide formation in the limbic forebrain and reduction of endocannabinoid contents in the striatum of delta9-tetrahydrocannabinol-tolerant rats.},
  author={Vincenzo Di Marzo and Fernando Berrendero and Tiziana Bisogno and Sergio G{\'o}mez Gonz{\'a}lez and Patti Cavaliere and Juli{\'a}n Esparza Romero and Maribel Cebeira and Jos{\'e} Antonio Vera Ramos and Javier J. Fernandez-Ruiz},
  journal={Journal of neurochemistry},
  year={2000},
  volume={74 4},
  pages={1627-35}
}
Recent studies have shown that the pharmacological tolerance observed after prolonged exposure to synthetic or plant-derived cannabinoids in adult rats is accompanied by down-regulation/desensitization of brain cannabinoid receptors. However, no evidence exists on possible changes in the contents of the endogenous ligands of cannabinoid receptors in the brain of cannabinoid-tolerant rats. The present study was designed to elucidate this possibility by measuring, by means of isotope dilution gas… CONTINUE READING
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