Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.

@article{Murayama1999EnhancementOA,
  title={Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.},
  author={Ohoshi Murayama and Taisuke Tomita and N Nihonmatsu and Miyuki Murayama and Xiaoyan Sun and Takeshi Honda and Takeshi Iwatsubo and Akihiko Takashima},
  journal={Neuroscience letters},
  year={1999},
  volume={265 1},
  pages={61-3}
}
Families bearing mutations in the presenilin 1 (PS1) gene develop early onset familial Alzheimer's disease (FAD). Further, some PS1 mutants enhance secretion of the longer form of amyloid beta protein (Abeta42). We constructed cDNAs encoding human PS1 harboring 28 FAD-linked mutations, and examined the effects of the expressed PS1 mutants on Abeta42 secretion in beta amyloid precursor producing COS-1 cells. All the mutants significantly enhanced the ratio of Abeta42 to total Abeta compared with… CONTINUE READING