Enhancement of aminopeptidase A expression during angiotensin II-induced choriocarcinoma cell proliferation through AT1 receptor involving protein kinase C- and mitogen-activated protein kinase-dependent signaling pathway.

@article{Ino2003EnhancementOA,
  title={Enhancement of aminopeptidase A expression during angiotensin II-induced choriocarcinoma cell proliferation through AT1 receptor involving protein kinase C- and mitogen-activated protein kinase-dependent signaling pathway.},
  author={Kazuhiko Ino and Carlos Uehara and Fumitaka Kikkawa and Hiroaki Kajiyama and Kiyosumi Shibata and Takahiro Suzuki and Ei Ei Khin and Mitsuaki Ito and Mikihito Takeuchi and Atsuo Itakura and Shigehiko Mizutani},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2003},
  volume={88 8},
  pages={3973-82}
}
Angiotensin II (Ang II) is a bioactive peptide of the renin-angiotensin system, exerting its actions not only as a vasoconstrictor, but also as a growth promoter. In human placenta, type 1 Ang II receptors (AT(1)R) are predominantly expressed in trophoblasts, and we previously reported that aminopeptidase A (APA), a cell surface peptidase that converts Ang II to Ang III, is also expressed in both normal and neoplastic trophoblasts. However, the roles of Ang II and APA in trophoblast function… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…