Enhancement of acetoin production in Candida glabrata by in silico-aided metabolic engineering

@inproceedings{Li2014EnhancementOA,
  title={Enhancement of acetoin production in Candida glabrata by in silico-aided metabolic engineering},
  author={Shubo Li and Xiang Gao and Nan Xu and Liming Liu and Jian Chen},
  booktitle={Microbial cell factories},
  year={2014}
}
BACKGROUND Acetoin is a promising chemical compound that can potentially serve as a high value-added platform for a broad range of applications. Many industrial biotechnological processes are moving towards the use of yeast as a platform. The multi-auxotrophic yeast, Candida glabrata, can accumulate a large amount of pyruvate, but produces only trace amounts of acetoin. Here, we attempted to engineer C. glabrata to redirect the carbon flux of pyruvate to increase acetoin production. RESULTS… CONTINUE READING

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