Enhancement of acetic acid tolerance in Saccharomyces cerevisiae by overexpression of the HAA1 gene, encoding a transcriptional activator.

@article{Tanaka2012EnhancementOA,
  title={Enhancement of acetic acid tolerance in Saccharomyces cerevisiae by overexpression of the HAA1 gene, encoding a transcriptional activator.},
  author={Koichi Tanaka and Yukari Ishii and Jun Ogawa and Jun Shima},
  journal={Applied and environmental microbiology},
  year={2012},
  volume={78 22},
  pages={8161-3}
}
Haa1 is a transcriptional activator required for Saccharomyces cerevisiae adaptation to weak acids. Here we show that the constitutive HAA1-overexpressing strain acquired a higher level of acetic acid tolerance. Under conditions of acetic acid stress, the intracellular level of acetic acid was significantly lower in HAA1-overexpressing cells than in the wild-type cells.