Enhancement of absorption and effect of glipizide by magnesium hydroxide.

@article{Kivist1991EnhancementOA,
  title={Enhancement of absorption and effect of glipizide by magnesium hydroxide.},
  author={Kari T. Kivist{\"o} and Pertti J Neuvonen},
  journal={Clinical pharmacology and therapeutics},
  year={1991},
  volume={49 1},
  pages={39-43}
}
The effects of magnesium hydroxide on the pharmacokinetics and pharmacodynamics of glipizide were studied in eight healthy volunteers in a randomized crossover trial. After an overnight fast, 5 mg glipizide was given with either 150 ml water or water containing 850 mg magnesium hydroxide. Magnesium hydroxide increased the areas under the plasma glipizide concentration-time curves (AUC) from 0 to 1/2 hour and from 0 to 1 hour by 180% (p less than 0.05) and 69% (p less than 0.05), respectively… CONTINUE READING

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