Enhancement of T-Cell-Depleted Bone Marrow Allografts in the Absence of Graft-Versus-Host Disease Is Mediated By CDS+ CD4- and Not By CDS- CD4+ Thymocytes

Abstract

Transplantation of T-cell-depleted C57BL/6-Nu/ Nu (“nude”) bone marrow (BM) into C3H/HeJ recipients, conditioned with 8 Gy total body irradiation plus chemotherapy with the myeloablative drug dimethyl myleran, resulted in poor hematopoietic reconstitution 14 days posttransplant, compared with transplantation with T-cell-depleted BM from normal C57BL/6 donors. Hematopoietic reconstitution of “nude” BM could be improved by the addition of (C57BL/6xC3H/ HeJ)FI thymocytes void of graft-versus-host activity. Enhancement of BM allografting by thymocytes is sensitive to low

Cite this paper

@inproceedings{Lapidot2003EnhancementOT, title={Enhancement of T-Cell-Depleted Bone Marrow Allografts in the Absence of Graft-Versus-Host Disease Is Mediated By CDS+ CD4- and Not By CDS- CD4+ Thymocytes}, author={Tsvee Lapidot and Yfat Faktorowich and Ido Lubin}, year={2003} }