Enhancement of Synaptic Plasticity through Chronically Reduced Ca2+ Flux during Uncorrelated Activity

@article{Slutsky2004EnhancementOS,
  title={Enhancement of Synaptic Plasticity through Chronically Reduced Ca2+ Flux during Uncorrelated Activity},
  author={Inna Slutsky and Safa Sadeghpour and Bing Li and Guosong Liu},
  journal={Neuron},
  year={2004},
  volume={44},
  pages={835-849}
}
The plasticity of synapses within neural circuits is regulated by activity, but the underlying mechanisms remain elusive. Using the dye FM1-43 to directly image presynaptic function, we found that large numbers of presynaptic terminals in hippocampal cultures have a low release probability. While these terminals were not readily modifiable, a transient but not permanent long-term reduction of network activity or Ca2+ influx could increase their modifiability. This modulation of plasticity was… CONTINUE READING