Enhancement of Sodium Current in NG108-15 Cells during Neural Differentiation is Mainly due to an Increase in NaV1.7 Expression

@article{Kawaguchi2007EnhancementOS,
  title={Enhancement of Sodium Current in NG108-15 Cells during Neural Differentiation is Mainly due to an Increase in NaV1.7 Expression},
  author={Akinori Kawaguchi and Hajime Asano and Kayoko Matsushima and Tetsuyuki Wada and Shigeru Yoshida and Seiji Ichida},
  journal={Neurochemical Research},
  year={2007},
  volume={32},
  pages={1469-1475}
}
It is well known that morphological and functional changes during neural differentiation sometimes accompany the expression of various voltage-gated ion channels. In this work, we investigated whether the enhancement of sodium current in differentiated neuroblastoma × glioma NG108-15 cells treated with dibutyryl cAMP is related to the expression of voltage-gated sodium channels. The results were as follows. (1) Sodium current density on peak voltage in differentiated cells was significantly… CONTINUE READING

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