Enhancement of Sleeping Beauty transposition by CpG methylation: possible role of heterochromatin formation.

@article{Yusa2004EnhancementOS,
  title={Enhancement of Sleeping Beauty transposition by CpG methylation: possible role of heterochromatin formation.},
  author={Kosuke Yusa and J. Takahashi Takeda and Kyoji Horie},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 9},
  pages={4004-18}
}
The Sleeping Beauty (SB) transposase is the most active transposase in vertebrate cells, and the SB transposon system has been used as a tool for insertional mutagenesis and gene delivery. Previous studies have indicated that the frequency of chromosomal transposition is considerably higher in mouse germ cells than in mouse embryonic stem cells, suggesting the existence of unknown mechanisms that regulate SB transposition. Here, we demonstrated that CpG methylation of the transposon region… CONTINUE READING

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