Enhancement of RNA Synthesis in Avian Liver Cell Cultures by a 5:-Steroid Metabolite During Induction of s-Aminolevulinate Synthase

Abstract

The porphyrin-heme pathway is controlled in the liver at the level of the mitochondrial enzyme 8-aminolevulinate synthase (EC 2.3.1.37), a protein inducible in cultured avian hepatocytes by a variety of chemicals including certain 5,3-metabolites of steroid hormones. The great sensitivity of the induction process to inhibition by agents known to block… (More)

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