Enhancement of Mycobacterium tuberculosis-induced tumor necrosis factor alpha production from primary human monocytes by an activated T-cell membrane-mediated mechanism.

Abstract

Mycobacterium tuberculosis alone induces small, donor-variable amounts of tumor necrosis factor alpha (TNF-alpha) from primary human monocytes in vitro. However, TNF-alpha release is increased 5- to 500-fold when fixed activated T cells (FAT) or their isolated, unfixed membranes are added to this system. This FAT-induced synergy was at least as potent as… (More)

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@article{WarwickDavies2001EnhancementOM, title={Enhancement of Mycobacterium tuberculosis-induced tumor necrosis factor alpha production from primary human monocytes by an activated T-cell membrane-mediated mechanism.}, author={J Warwick-Davies and Amanda Watson and George E. Griffin and Sanjeev Krishna and Robin J Shattock}, journal={Infection and immunity}, year={2001}, volume={69 11}, pages={6580-7} }