Enhancement of Muscle T Regulatory Cells and Improvement of Muscular Dystrophic Process in mdx Mice by Blockade of Extracellular ATP/P2X Axis.

@article{Gazzerro2015EnhancementOM,
  title={Enhancement of Muscle T Regulatory Cells and Improvement of Muscular Dystrophic Process in mdx Mice by Blockade of Extracellular ATP/P2X Axis.},
  author={Elisabetta Gazzerro and Simona Baldassari and Stefania Assereto and Floriana Fruscione and Angela Pistorio and Chiara Panicucci and Stefano Volpi and Lisa Perruzza and Chiara Fiorillo and Carlo Minetti and Elisabetta Traggiai and Fabio Grassi and Claudio Bruno},
  journal={The American journal of pathology},
  year={2015},
  volume={185 12},
  pages={3349-60}
}
Infiltration of immune cells and chronic inflammation substantially affect skeletal and cardiac muscle degeneration in Duchenne muscular dystrophy. In the immune system, extracellular adenosine triphosphate (ATP) released by dying cells is sensed as a danger associated molecular pattern through P2 purinergic receptors. Specifically, the P2X7 subtype has a prominent role in regulating immune system physiology and contributes to inflammasome activation also in muscle cells. Here, we show that in… CONTINUE READING