Enhancement of MEK/ERK signaling promotes glucocorticoid resistance in CD4+ T cells.

@article{Tsitoura2004EnhancementOM,
  title={Enhancement of MEK/ERK signaling promotes glucocorticoid resistance in CD4+ T cells.},
  author={Daphne C. Tsitoura and Paul B. Rothman},
  journal={The Journal of clinical investigation},
  year={2004},
  volume={113 4},
  pages={619-27}
}
Glucocorticoids have potent immunosuppressive properties, but their effects are often modulated by the conditions prevailing in the local immune milieu. In this study we determined whether the action of glucocorticoids is influenced by the degree of signaling during T cell activation. We found that dexamethasone (Dex) effectively suppressed T cell receptor-induced (TCR-induced) proliferation of naive CD4+ T cells, through a mechanism involving downregulation of c-Fos expression and inhibition… CONTINUE READING

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Identification of a novel inhibitor of mitogen- activated protein kinase kinase

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