Enhancement of Infection by Pre-Existing Non-Neutralizing Antibodies to Cross-Reactive Flaviviruses: Ramifications for Vaccination against Dengue and Zika

  title={Enhancement of Infection by Pre-Existing Non-Neutralizing Antibodies to Cross-Reactive Flaviviruses: Ramifications for Vaccination against Dengue and Zika},
  author={Andrew W. Taylor-Robinson},
Dengue is a prominent mosquito-transmitted viral disease of humans that is a significant public health consideration in tropical and subtropical regions of the world in which it is endemic. Cross-reactivity between different serotypes of dengue virus activates antibody-dependent enhancement of infections, an immunopathological response that it is thought to amplify viral replication and thereby to increase disease severity. The hitherto neglected closely related flavivirus Zika has now emerged… 
2 Citations

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Dengue Virus Immunopathogenesis: Lessons Applicable to the Emergence of Zika Virus.

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Dengue is a serious re-emerging arboviral disease that presents a global human health challenge. Infection is caused by one of several recognised serotypes of dengue virus, a member of the

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These studies establish that human and mouse antibodies recognize distinct epitopes on the dengue virion, and indicate that antibody neutralization of DENVs is a “multi-hit” phenomenon that requires the binding of multiple antibodies to neutralize a virion.

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The first d Dengue vaccine, a recombinant yellow fever-17D–dengue virus, live, attenuated, tetravalent dengue vaccine (CYD-TDV; Dengvaxia, Sanofi Pasteur, Singapore, Singapore), has recently been licensed for use in individuals aged from 9 to 45 years in Mexico, Brazil, the Philippines, El Salvador, and Paraguay.

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The potential impact of the existence of DENV-5 and other sylvatic arboviruses on the strategy to combat dengue fever and related pyrexias of unknown origin should be considered in order to refine guidelines for diagnosis, treatment, prevention and control.

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