Enhancement of Infection by Pre-Existing Non-Neutralizing Antibodies to Cross-Reactive Flaviviruses: Ramifications for Vaccination against Dengue and Zika

@inproceedings{TaylorRobinson2017EnhancementOI,
  title={Enhancement of Infection by Pre-Existing Non-Neutralizing Antibodies to Cross-Reactive Flaviviruses: Ramifications for Vaccination against Dengue and Zika},
  author={Andrew W. Taylor-Robinson},
  year={2017}
}
Dengue is a prominent mosquito-transmitted viral disease of humans that is a significant public health consideration in tropical and subtropical regions of the world in which it is endemic. Cross-reactivity between different serotypes of dengue virus activates antibody-dependent enhancement of infections, an immunopathological response that it is thought to amplify viral replication and thereby to increase disease severity. The hitherto neglected closely related flavivirus Zika has now emerged… 
2 Citations

Dengue Infection in Indonesia: Improved Clinical Profiling Is Needed to Better Inform Patient Management and Disease Outbreak Control

There is a pressing need to understand in more detail the clinical profile of dengue outbreaks in tertiary hospitals in Jakarta, the capital and most populous city, to enhance patient care and better inform future prevention and control strategies for this emerging public health threat.

Spatial Clustering of Dengue Fever Incidence and Its Association with Surrounding Greenness

This study aims to assess the spatial autocorrelation of the dengue fever (DF) outbreak in southern Taiwan in 2014 and 2015, and to further understand the effects of green space (such as forests, farms, grass, and parks) allocation on DF.

References

SHOWING 1-10 OF 63 REFERENCES

Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus

Plasma immune to DENV showed substantial cross-reaction to ZIKV and was able to drive antibody-dependent enhancement (ADE) of ZikaV infection, indicating that immunity toDENV might drive greater ZikV replication and have clear implications for disease pathogenesis and future vaccine programs.

Dengue virus antibodies enhance Zika virus infection

It is suggested that pre-existing DENV immunity will enhance ZIKV infection in vivo and may increase disease severity, and neutralizing and enhancing potential of well-characterized broadly neutralizing human anti-DENV monoclonal antibodies and human DENV immune sera against ZikV are tested.

Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection

The most potent neutralizing antibodies were ZIKV-specific and targeted EDIII or quaternary epitopes on infectious virus, and an EDIII-targeted antibody protected mice against lethal infection, illustrating the potential for antibody-based therapy.

Dengue Virus Immunopathogenesis: Lessons Applicable to the Emergence of Zika Virus.

Vigilance to Limit the Bidirectional Introduction and Co-circulation of Virus Serotypes Aims to Reduce Risk of Severe Dengue Disease in North East India

Dengue is a serious re-emerging arboviral disease that presents a global human health challenge. Infection is caused by one of several recognised serotypes of dengue virus, a member of the

The Human Antibody Response to Dengue Virus Infection

These studies establish that human and mouse antibodies recognize distinct epitopes on the dengue virion, and indicate that antibody neutralization of DENVs is a “multi-hit” phenomenon that requires the binding of multiple antibodies to neutralize a virion.

The first licensed dengue vaccine: an important tool for integrated preventive strategies against dengue virus infection

The first d Dengue vaccine, a recombinant yellow fever-17D–dengue virus, live, attenuated, tetravalent dengue vaccine (CYD-TDV; Dengvaxia, Sanofi Pasteur, Singapore, Singapore), has recently been licensed for use in individuals aged from 9 to 45 years in Mexico, Brazil, the Philippines, El Salvador, and Paraguay.

A Putative Fifth Serotype of Dengue - Potential Implications for Diagnosis, Therapy and Vaccine Design

The potential impact of the existence of DENV-5 and other sylvatic arboviruses on the strategy to combat dengue fever and related pyrexias of unknown origin should be considered in order to refine guidelines for diagnosis, treatment, prevention and control.

Zika Virus-Induced Antibody Response Enhances Dengue Virus Serotype 2 Replication In Vitro.

It is shown that Zika virus antibodies have the ability to enhance d Dengue virus infections, which is important, because in many Zika virus-affected areas, dengue virus is expected to remain endemic.
...