Enhancement of Fear Extinction with Deep Brain Stimulation: Evidence for Medial Orbitofrontal Involvement

@article{RodriguezRomaguera2015EnhancementOF,
  title={Enhancement of Fear Extinction with Deep Brain Stimulation: Evidence for Medial Orbitofrontal Involvement},
  author={Jose Rodriguez-Romaguera and Fabr{\'i}cio H M Do-Monte and Yoko Tanimura and Gregory J Quirk and Suzanne N. Haber},
  journal={Neuropsychopharmacology},
  year={2015},
  volume={40},
  pages={1726-1733}
}
Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) reduces anxiety, fear, and compulsive symptoms in patients suffering from refractory obsessive-compulsive disorder. In a rodent model, DBS-like high-frequency stimulation of VS can either enhance or impair extinction of conditioned fear, depending on the location of electrodes within VS (dorsal vs ventral). As striatal DBS activates fibers descending from the cortex, we reasoned that the differing effects on extinction… CONTINUE READING
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