Enhancement of DNA vaccine-induced immune responses by a 72-bp element from SV40 enhancer.

@article{Li2007EnhancementOD,
  title={Enhancement of DNA vaccine-induced immune responses by a 72-bp element from SV40 enhancer.},
  author={Hai-shan Li and Yong Liu and Ding-feng Li and Ran-ran Zhang and Hai-li Tang and Yu-wei Zhang and Wei Huang and Ying Yu Liu and Hong Rui Peng and Jian-qing Xu and Kun-xue Hong and Yongzhao Shao},
  journal={Chinese medical journal},
  year={2007},
  volume={120 6},
  pages={
          496-502
        }
}
BACKGROUND Although DNA vaccine is considered as the next generation of vaccine, most DNA vaccine candidates are still suffering from the relatively weak immunogenicity despite the increased dosage of plasmid DNA administered. In order to enhance the immune responses elicited by a codon-optimized HIV gag DNA vaccine, a modified plasmid vector pDRVI1.0 and a booster immunization with replicating Tiantan vaccinia (RTV) strain expressing the same gene were employed. METHODS Vector pDRVI1.0 was… CONTINUE READING