Enhancement of DNA repair in human skin cells by thymidine dinucleotides: evidence for a p53-mediated mammalian SOS response.

@article{Eller1997EnhancementOD,
  title={Enhancement of DNA repair in human skin cells by thymidine dinucleotides: evidence for a p53-mediated mammalian SOS response.},
  author={Mark S. Eller and Tsutomu Maeda and Cristina Magnoni and D Atwal and Barbara A. Gilchrest},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 23},
  pages={12627-32}
}
Thymidine dinucleotide (pTpT) stimulates melanogenesis in mammalian pigment cells and intact skin, mimicking the effects of UV irradiation and UV-mimetic DNA damage. Here it is shown that, in addition to tanning, pTpT induces a second photoprotective response, enhanced repair of UV-induced DNA damage. This enhanced repair results in a 2-fold increase in expression of a UV-damaged chloramphenicol acetyltransferase expression vector transfected into pTpT-treated skin fibroblasts and keratinocytes… CONTINUE READING

8 Figures & Tables

Connections & Topics

Mentioned Connections BETA
These effects of pTpT are accomplished , at least in part , by the up - regulation of a set of genes involved in DNA repair ( ERCC3 and GADD45 ) and cell cycle inhibition ( SDI1 ) .
These effects of pTpT are accomplished , at least in part , by the up - regulation of a set of genes involved in DNA repair ( ERCC3 and GADD45 ) and cell cycle inhibition ( SDI1 ) .
DNA RepairProcess involves geneGADD45A wt Allele
These effects of pTpT are accomplished , at least in part , by the up - regulation of a set of genes involved in DNA repair ( ERCC3 and GADD45 ) and cell cycle inhibition ( SDI1 ) .
Enhancement of DNA repair in human skin cells by thymidine dinucleotides : evidence for a p53-mediated mammalian SOS response .
All Topics