Enhancement of DNA cleavage activity of an unnatural ferrocene-amino acid conjugate.

@article{Higgins2009EnhancementOD,
  title={Enhancement of DNA cleavage activity of an unnatural ferrocene-amino acid conjugate.},
  author={Pamela J Higgins and Amanda M Gellett},
  journal={Bioorganic & medicinal chemistry letters},
  year={2009},
  volume={19 6},
  pages={1614-7}
}
The nucleolytic activity of an unnatural ferrocenyl amino acid can be significantly enhanced under reducing or Fenton conditions while exploiting different mechanisms of DNA cleavage. In addition, results from high resolution electrophoresis indicate that the ferrocenyl amino acid exhibits non-sequence specific cleavage of the DNA backbone.