Enhancement of Clostridium difficile toxin production in biotin-limited conditions.

@article{Yamakawa1996EnhancementOC,
  title={Enhancement of Clostridium difficile toxin production in biotin-limited conditions.},
  author={Koji Yamakawa and Tadahiro Karasawa and Sinya Ikoma and Shin-ichi Nakamura},
  journal={Journal of medical microbiology},
  year={1996},
  volume={44 2},
  pages={111-4}
}
The effect of biotin on toxin production by Clostridium difficile was examined in a defined medium. When toxin production by strain KZ 1647, which was isolated from a healthy adult, was examined in relation to its biotin requirement, it was found that with decreasing concentrations of biotin, bacterial growth was decreased, but production of both toxins A and B were remarkably increased, particularly with 0.05 nM biotin. The time course of production of both toxins in biotin-limited conditions… CONTINUE READING