Enhancement of Central Dopaminergic Activity in the Kainate Model of Temporal Lobe Epilepsy: Implication for the Mechanism of Epileptic Psychosis

@article{Ando2004EnhancementOC,
  title={Enhancement of Central Dopaminergic Activity in the Kainate Model of Temporal Lobe Epilepsy: Implication for the Mechanism of Epileptic Psychosis},
  author={Nobuo Ando and Kiyoshi Sawai Takashi Morimoto and Takemi Watanabe and Takashi Ninomiya and Hiroshi Suwaki},
  journal={Neuropsychopharmacology},
  year={2004},
  volume={29},
  pages={1251-1258}
}
There is an increased incidence of schizophrenia-like psychosis in temporal lobe epilepsy (TLE), and several risk factors have been implicated, including the duration of epilepsy and temporal lobe neuropathology. To investigate the biological mechanism of epileptic psychosis, we examined alterations of central dopaminergic systems in the kainate model of TLE. In adult rats, kainate was microinjected into the left amygdala to induce status epilepticus. An indirect dopamine agonist… CONTINUE READING
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